Originally I had upgraded from Vista to build 7068 then to 7077, besides a few quibbles, namely apps in the Start up folder not starting, the ATI Catalyst 9.4 drivers not installing and some of my gadgets not working, I didn't have any major issues and it worked a champ.
I did end up doing a full/fresh install of 7077 over the weekend and am quite happy, to the point that I'm seriously considering leaving it alone for 6 months before I rebuild again.